Emergence of adenomatous aberrant crypt foci (ACF) from hyperplastic ACF with concomitant increase in cell proliferation.

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Article

Emergence of adenomatous aberrant crypt foci (ACF) from hyperplastic ACF with concomitant increase in cell proliferation.

Cancer research - 1 Nov 1995

Otori K, Sugiyama K, Hasebe T, Fukushima S, Esumi H

Abstract excerpt

To investigate the relationship between aberrant crypt foci (ACF) and colon neoplasia in colorectal carcinogenesis, we evaluated 433 ACF, which were collected from the grossly normal mucosa of surgical specimens from 57 patients with colorectal cancer. The ACF ranged in size from 3 to 412 aberran...

Topics

Adult
Aged
Aged, 80 and over
Cell Division
Cell Transformation, Neoplastic
Codon
Colorectal Neoplasms
Female
Genes, ras
Humans
Hyperplasia
Immunohistochemistry
Intestinal Mucosa
Male
Middle Aged
Mutation
Precancerous Conditions
Proliferating Cell Nuclear Antigen

Source

Open in PubMed

Identifiers

PMID: 7585496

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7585496-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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