Article
A role for the cytoplasmic tail of the beta chain of CD8 in thymic selection.
Immunity - 1 Jul 1994
Itano A, Cado D, Chan F K, Robey E
Abstract excerpt
The CD8 coreceptor plays a critical role in the recognition of foreign antigens by mature T cells and in the development of class I-restricted T cells. CD8 can be expressed on the surface of T cells as either a heterodimer composed of an alpha and beta chain, or as a homodimer composed of two alpha chains. In this report, we show that a CD8 beta transgene that lacks a cytoplasmic domain can suppress expression of...
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