Article
Beta-chain broadens range of CD8 recognition for MHC class I molecule.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 1992
Karaki S, Tanabe M, Nakauchi H, Takiguchi M
Abstract excerpt
It is known that the alpha-chain of CD8 binds to a negatively charged loop composed of residues 223 to 229 on MHC class I Ag and that binding of CD8 alpha enhances Ag recognition of T cells. We have recently shown that the mouse CD8 alpha homodimer does not bind to either the HLA class I alpha 3 domain or a mutant of H-2Kb Ag containing a substitution of glutamine for methionine at residue 224, which brings this...
Topics
- Animals
- Antibodies, Monoclonal
- Binding Sites
- CD8 Antigens
- H-2 Antigens
- Histocompatibility Antigens Class I
- Hybridomas
- Mice
- Mutation
- Transfection