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Article

Positive selecting cell type determines the phenotype of MHC class Ib-restricted CD8+ T cells.

Proceedings of the National Academy of Sciences of the United States of America - 9 Aug 2011

Cho Hoonsik, Bediako Yaw, Xu Honglin, Choi Hak-Jong, Wang Chyung-Ru

Abstract excerpt

Several studies have demonstrated an apparent link between positive selection on hematopoietic cells (HCs) and an "innate" T-cell phenotype. Whereas conventional CD8(+) T cells are primarily selected on thymic epithelial cells (TECs) and certain innate T cells are exclusively selected on HCs, MHC class Ib-restricted CD8(+) T cells appear to be selected on both TECs and HCs. However, whether TEC- and HC-selected T...

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Identifiers

PMID: 21788511
DOI: 10.1073/pnas.1105118108
PMCID: PMC3156174

Genes

TEC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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