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Article

Designing zinc-finger ADR1 mutants with altered specificity of DNA binding to T in UAS1 sequences.

Biochemistry - 14 Mar 1995

Taylor W E, Suruki H K, Lin A H, Naraghi-Arani P, Igarashi R Y, Younessian M, Katkus P, Vo N V

Abstract excerpt

Yeast ADR1 contains two Cys2,His2 zinc fingers needed for DNA binding to the upstream activation sequence UAS1, with bases T5T6G7-G8A9G10 in the ADH2 promoter. Potential DNA-contacting amino acid residues at -1, +3, and +6 in the alpha-helical domains of ADR1's fingers one and two include RHR-RLR; however, the latter finger two residues Leu146 and Arg149 had not proved to be crucial for ADR1 binding, even though...

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PMID: 7880816
DOI: 10.1021/bi00010a011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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