Article
Two zinc fingers of a yeast regulatory protein shown by genetic evidence to be essential for its function.
Nature - 1 Jan 2000
Blumberg H, Eisen A, Sledziewski A, Bader D, Young E T
Abstract excerpt
The best-understood protein structure involved in DNA binding is the helix-turn-helix motif. A second DNA-binding domain, the finger structure, has been proposed on the basis of sequence analysis, partial proteolysis and zinc content of Xenopus transcription factor TFIIIA. Other eukaryotic proteins were subsequently found to contain contiguous repeat units of the postulated finger motif. Each repeat unit contains...
Topics
- Amino Acid Sequence
- Cysteine
- DNA
- DNA-Binding Proteins
- Fungal Proteins
- Histidine
- Metalloproteins
- Mutation
- Phenotype
- Protein Conformation
- Saccharomyces cerevisiae