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Article

A mutation outside the two zinc fingers of ADR1 can suppress defects in either finger.

Molecular and cellular biology - 1 Dec 1992

Camier S, Kacherovsky N, Young E T

Abstract excerpt

A second-site mutation that restored DNA binding to ADR1 mutants altered at different positions in the two zinc fingers was identified. This mutation (called IS1) was a conservative change of arginine 91 to lysine in a region amino terminal to the two zinc fingers and known from previous experiments to be necessary for DNA binding. IS1 increased binding to the UAS1 sequence two- to sevenfold for various ADR1...

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Identifiers

PMID: 1448103
DOI: 10.1128/mcb.12.12.5758-5767.1992
PMCID: PMC360515

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