Article
A mutation outside the two zinc fingers of ADR1 can suppress defects in either finger.
Molecular and cellular biology - 1 Dec 1992
Camier S, Kacherovsky N, Young E T
Abstract excerpt
A second-site mutation that restored DNA binding to ADR1 mutants altered at different positions in the two zinc fingers was identified. This mutation (called IS1) was a conservative change of arginine 91 to lysine in a region amino terminal to the two zinc fingers and known from previous experiments to be necessary for DNA binding. IS1 increased binding to the UAS1 sequence two- to sevenfold for various ADR1...
Topics
- Alleles
- Amino Acid Sequence
- Binding Sites
- DNA-Binding Proteins
- Fungal Proteins
- Molecular Sequence Data
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Suppression, Genetic
- Transcription Factors
- Zinc Fingers