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Article

Structures of DNA-binding mutant zinc finger domains: implications for DNA binding.

Protein science : a publication of the Protein Society - 1 Jun 1993

Hoffman R C, Horvath S J, Klevit R E

Abstract excerpt

Studies of Cys2-His2 zinc finger domains have revealed that the structures of individual finger domains in solution determined by NMR spectroscopy are strikingly similar to the structure of fingers bound to DNA determined by X-ray diffraction. Therefore, detailed structural analyses of single finger domains that contain amino acid substitutions known to affect DNA binding in the whole protein can yield...

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Identifiers

PMID: 8318900
DOI: 10.1002/pro.5560020609
PMCID: PMC2142395

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