Article
A tryptophan-rich peptide acts as a transcription activation domain.
BMC molecular biology - 16 Nov 2010
Lin Chen-Huan, Lin Grace, Chang Chia-Pei, Wang Chien-Chia
Abstract excerpt
BACKGROUND: Eukaryotic transcription activators normally consist of a sequence-specific DNA-binding domain (DBD) and a transcription activation domain (AD). While many sequence patterns and motifs have been defined for DBDs, ADs do not share easily recognizable motifs or structures. RESULTS: We report herein that the N-terminal domain of yeast valyl-tRNA synthetase can function as an AD when fused to a...
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