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Article

Influence of the lpr environment on the lymph node cell phenotypes in C57BL/6 nubg and nulpr chimeras.

Immunology - 1 Dec 1994

Tiberghien F, Ceredig R, Loor F

Abstract excerpt

Mice homozygous for the lpr gene show a marked lymphoproliferative syndrome. Most T cells which accumulate in their lymphoid organs belong to a fairly unusual subpopulation. Although being CD44+ T cells expressing neither CD4 nor CD8, they are CD3 T-cell receptor (TCR) alpha beta positive and express both Thy-1 and B220, the B-cell form of the CD45 marker. To support engraftment and development of transferred lpr...

Topics

Animals
Autoimmune Diseases
Bone Marrow Transplantation
Immunophenotyping
Lymph Nodes
Lymphoproliferative Disorders
Mice
Mice, Inbred C57BL
Mice, Nude
Mutation
Species Specificity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Spleen

T-Lymphocyte Subsets

Thymus Gland

Transplantation Chimera

Source

Open in PubMed Open full text

Identifiers

PMID: 7875735
PMCID: PMC1415060

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7875735-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Influence of the lpr environment on the lymph node cell phenotypes in C57BL/6 nubg and nulpr chimeras.PMID 7875735Read ↗

Lymphadenopathy induced by the cooperation between lprcg and gld genes is of lpr but not of gld phenotype.Semantic proximity Read ↗

Different expression of T-cell receptor beta-chain variable region genes in lymph nodes of lpr mice with different alleles of the major histocompatibility complex.Semantic proximity Read ↗

The proliferative in vivo activities of lpr double-negative T cells and the primary role of p59fyn in their activation and expansionSemantic proximity Read ↗

Haematopoietic cell transfers between C57BL/6 mice differing at the lpr or gld locus.Semantic proximity Read ↗

Leukemia development initiated by deletion of RBP-J: mouse strain, deletion efficiency and cell of origin.Semantic proximity Read ↗

Differences defined by bone marrow transplantation suggest that lpr and gld are mutations of genes encoding an interacting pair of molecules.Semantic proximity Read ↗

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Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant mice.Semantic proximity Read ↗

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Bone marrow transplantation from mutant lpr/lpr mice. Functional abnormalities rather than alloantigenic differences appear to determine the development of a graft-vs.-host-like syndrome.Semantic proximity Read ↗

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