Article
Leukemia development initiated by deletion of RBP-J: mouse strain, deletion efficiency and cell of origin.
Disease models & mechanisms - 18 Dec 2018
Belyea Brian Chipman, Xu Fang, Sequeira-Lopez Maria Luisa Soledad, Gomez Roberto Ariel
Abstract excerpt
Conditional deletion of RBP-J, the major transcriptional effector of Notch signaling, specifically within renin-expressing cells leads to the development of B-cell leukemia. However, the influence of contributing factors such as mouse strain, cell of origin and Cre recombinase copy number are unknown. In this study, we compared RBP-J deletion efficiency using one versus two copies of Cre recombinase. Further, we...
Topics
- Animals
- B-Lymphocytes
- Carcinogenesis
- Cell Lineage
- Cell Transformation, Neoplastic
- Dermatitis
- Gene Deletion
- Gene Dosage
- Hematopoiesis
- Immunoglobulin J Recombination Signal Sequence-Binding Protein
- Integrases
- Leukemia
- Mice, Inbred C57BL
- Phenotype