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Article

Leukemia development initiated by deletion of RBP-J: mouse strain, deletion efficiency and cell of origin.

Disease models & mechanisms - 18 Dec 2018

Belyea Brian Chipman, Xu Fang, Sequeira-Lopez Maria Luisa Soledad, Gomez Roberto Ariel

Abstract excerpt

Conditional deletion of RBP-J, the major transcriptional effector of Notch signaling, specifically within renin-expressing cells leads to the development of B-cell leukemia. However, the influence of contributing factors such as mouse strain, cell of origin and Cre recombinase copy number are unknown. In this study, we compared RBP-J deletion efficiency using one versus two copies of Cre recombinase. Further, we...

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Identifiers

PMID: 30467111
DOI: 10.1242/dmm.036731
PMCID: PMC6307899

Genes

CD19

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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