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Article

Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain.

Nature - 2 Mar 1995

Picciotto M R, Zoli M, Léna C, Bessis A, Lallemand Y, Le Novère N, Vincent P, Pich E M, Brûlet P, Changeux J P

Abstract excerpt

Nicotine affects many aspects of behaviour including learning and memory through its interaction with neuronal nicotinic acetylcholine receptors (nAChR). Functional nAChRs are pentameric proteins containing at least one type of alpha-subunit and one type of beta-subunit. The involvement of a particular neuronal nicotinic subunit in pharmacology and behaviour was examined using gene targeting to mutate beta 2, the...

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PMID: 7870173
DOI: 10.1038/374065a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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