Article
Increased sensitivity to nicotine-induced seizures in mice expressing the L250T alpha 7 nicotinic acetylcholine receptor mutation.
Molecular pharmacology - 1 Mar 2002
Broide Ron S, Salas Ramiro, Ji Daoyun, Paylor Richard, Patrick James W, Dani John A, De Biasi Mariella
Abstract excerpt
High doses of nicotine, the addictive component of tobacco, induce clonic-tonic seizures in animals. Pharmacological and biochemical data have suggested that alpha 7-containing neuronal nicotinic receptors (nAChRs) contribute to these seizures. To study potential alpha 7 contributions, we examined alpha 7 subunits with a Leu250-to-Thr substitution in the channel domain, which creates a gain-of-function mutation....
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