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Article

Nicotine physical dependence in the mouse: involvement of the alpha7 nicotinic receptor subtype.

European journal of pharmacology - 16 May 2005

Grabus Sheri D, Martin Billy R, Imad Damaj M

Abstract excerpt

Although chronic nicotine produces dependence in mice, the role of specific nicotinic receptors has not been examined in knockout animals. The present study utilized alpha7 nicotinic receptor knockout mice to explore the role of this receptor subunit in nicotine dependence. Mice were chronically exposed to nicotine (0 or 200 microg/ml) in their drinking water and assayed for somatic withdrawal signs, hyperalgesia...

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Source

Identifiers

PMID: 15896732
DOI: 10.1016/j.ejphar.2005.03.044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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