Alterations of cortical pyramidal neurons in mice lacking high-affinity nicotinic receptors.

doi:10.1073/pnas.1006269107

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Article

Alterations of cortical pyramidal neurons in mice lacking high-affinity nicotinic receptors.

Proceedings of the National Academy of Sciences of the United States of America - 22 Jun 2010

Ballesteros-Yáñez Inmaculada, Benavides-Piccione Ruth, Bourgeois Jean-Pierre, Changeux Jean-Pierre, DeFelipe Javier

Abstract excerpt

The neuronal nicotinic acetylcholine receptors (nAChRs) are allosteric membrane proteins involved in multiple cognitive processes, including attention, learning, and memory. The most abundant form of heterooligomeric nAChRs in the brain contains the beta2- and alpha4- subunits and binds nicotinic agonists with high affinity. In the present study, we investigated in the mouse the consequences of the deletion of...

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Identifiers

PMID: 20534523
DOI: 10.1073/pnas.1006269107
PMCID: PMC2895077

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.