Article
Phenotypic characterization of an alpha 4 neuronal nicotinic acetylcholine receptor subunit knock-out mouse.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Sept 2000
Ross S A, Wong J Y, Clifford J J, Kinsella A, Massalas J S, Horne M K, Scheffer I E, Kola I, Waddington J L, Berkovic S F, Drago J
Abstract excerpt
Neuronal nicotinic acetylcholine receptors (nAChR) are present in high abundance in the nervous system (Decker et al., 1995). There are a large number of subunits expressed in the brain that combine to form multimeric functional receptors. We have generated an alpha(4) nAChR subunit knock-out line and focus on defining the behavioral role of this receptor subunit. Homozygous mutant mice (Mt) are normal in size,...
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