An early post-mutational selection event directs expansion of autoreactive B cells in murine lupus.

doi:10.1016/0161-5890(94)00129-o

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Article

An early post-mutational selection event directs expansion of autoreactive B cells in murine lupus.

Molecular immunology - 1 Feb 1995

Portanova J P, Creadon G, Zhang X, Smith D S, Kotzin B L, Wysocki L J

Abstract excerpt

We report evidence for a strong selection event directing the outgrowth of autoreactive B cells in spontaneous murine lupus. The event occurred shortly following the induction of the somatic hypermutation process. This conclusion is derived from extensive sequence analyses of VH and VL loci expressed by hybridomas representing two large histone-specific clones (lineages) from an autoimmune (NZB x SWR)F1 mouse. To...

Topics

Amino Acid Sequence
Animals
Antibodies, Antinuclear
B-Lymphocytes
Base Sequence
Clone Cells
Gene Amplification
Histones
Hybridomas
Immunologic Techniques
Lupus Erythematosus, Systemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred BALB C

Mice, Inbred NZB

Mice, Inbred Strains

Molecular Sequence Data

Mutation

Source

Open in PubMed

Identifiers

PMID: 7870064
DOI: 10.1016/0161-5890(94)00129-o

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7870064-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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