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Article

The role of clonal selection and somatic mutation in autoimmunity.

Nature - 1 Jan 2000

Shlomchik M J, Marshak-Rothstein A, Wolfowicz C B, Rothstein T L, Weigert M G

Abstract excerpt

Polyclonal activation has been proposed as the reason that autoantibodies are produced during autoimmune disease. This model denies a role for specific antigen selection of B cells and predicts instead a multiclonal population of unmutated or randomly mutated autoantibodies. We have found that the genetic features and clonal composition of spontaneously derived immunoglobulin G (IgG) antiself-IgG (rheumatoid...

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PMID: 3498121
DOI: 10.1038/328805a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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