The role of clonal selection and somatic mutation in autoimmunity.

doi:10.1038/328805a0

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Article

The role of clonal selection and somatic mutation in autoimmunity.

Nature - 1 Jan 2000

Shlomchik M J, Marshak-Rothstein A, Wolfowicz C B, Rothstein T L, Weigert M G

Abstract excerpt

Polyclonal activation has been proposed as the reason that autoantibodies are produced during autoimmune disease. This model denies a role for specific antigen selection of B cells and predicts instead a multiclonal population of unmutated or randomly mutated autoantibodies. We have found that th...

Topics

Amino Acid Sequence
Animals
Autoantibodies
Autoantigens
Autoimmune Diseases
B-Lymphocytes
Base Sequence
Clone Cells
Hybridomas
Immunoglobulin G
Lymphocyte Activation
Mice
Mice, Inbred BALB C
Mice, Inbred C3H
Mutation
Rheumatoid Factor

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