Article
Two Distinct Pathways in Mice Generate Antinuclear Antigen-Reactive B Cell Repertoires.
Frontiers in immunology - 1 Jan 2018
Faderl Martin, Klein Fabian, Wirz Oliver F, Heiler Stefan, Albertí-Servera Llucia, Engdahl Corinne, Andersson Jan, Rolink Antonius
Abstract excerpt
The escape of anti-self B cells from tolerance mechanisms like clonal deletion, receptor editing, and anergy results in the production of autoantibodies, which is a hallmark of many autoimmune disorders. In this study, we demonstrate that both germline sequences and somatic mutations contribute to autospecificity of B cell clones. For this issue, we investigated the development of antinuclear autoantibodies...
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