Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Somatic hypermutation as a generator of antinuclear antibodies in a murine model of systemic autoimmunity

30 Aug 2010

Abstract excerpt

Systemic lupus erythematosus (SLE) is characterized by high-avidity IgG antinuclear antibodies (ANAs) that are almost certainly products of T cell-dependent immune responses. Whether critical amino acids in the third complementarity-determining region (CDR3) of the ANA originate from V(D)J recombination or somatic hypermutation (SHM) is not known. We studied a mouse model of SLE in which all somatic mutations...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Cell Function and Interaction
Share to Monoclonal and Polyclonal Antibodies Research
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20805563
DOI: 10.1084/jem.20092712

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 16 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Somatic hypermutation as a generator of antinuclear antibodies in a murine model of systemic autoimmunityPMID 20805563Read ↗

Correlation between the amino acid position of arginine in VH-CDR3 and specificity for native DNA among autoimmune antibodiesSemantic proximity Read ↗

Two Distinct Pathways in Mice Generate Antinuclear Antigen-Reactive B Cell Repertoires.Semantic proximity Read ↗

The role of somatic hypermutation in the generation of pathogenic antibodies in SLESemantic proximity Read ↗

Clonal evolution and antigen recognition of anti-nuclear antibodies in acute systemic lupus erythematosus.Semantic proximity Read ↗

Secondary mechanisms of diversification in the human antibody repertoireSemantic proximity Read ↗

Molecular characteristics of antibodies bearing an anti-DNA-associated idiotype.Semantic proximity Read ↗

DNA repair mechanisms that promote insertion-deletion events during immunoglobulin gene diversification.Semantic proximity Read ↗

Nucleotide Insertions and Deletions Complement Point Mutations to Massively Expand the Diversity Created by Somatic Hypermutation of AntibodiesSemantic proximity Read ↗

Somatic diversification and affinity maturation of IgM and IgG anti-DNA antibodies in murine lupus.Semantic proximity Read ↗

Self-reactive B cells traverse a perfect storm of somatic mutagenesis to cause a virus-induced autoimmune diseaseSemantic proximity Read ↗

T cell-independent somatic hypermutation in murine B cells with an immature phenotype.Semantic proximity Read ↗

Human Peripheral Blood Antibodies with Long HCDR3s Are Established Primarily at Original Recombination Using a Limited Subset of Germline GenesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.