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Article

Frequent loss of heterozygosity in the region including BRCA1 on chromosome 17q in squamous cell carcinomas of the esophagus.

Cancer research - 1 Apr 1994

Mori T, Aoki T, Matsubara T, Iida F, Du X, Nishihira T, Mori S, Nakamura Y

Abstract excerpt

Ninety-four esophageal squamous cell carcinomas were examined for loss of heterozygosity at several loci on the long arm of chromosome 17 (17q), using restriction fragment length polymorphism markers. Loss of heterozygosity was observed in 56 (62%) of 91 tumors that were informative with at least one marker. Comparison of these results with clinicopathological data indicated that the losses on chromosome 17q had...

Topics

Alleles
Blotting, Southern
Carcinoma, Squamous Cell
Chromosome Banding
Chromosome Deletion
Chromosome Mapping
Chromosomes, Human, Pair 17
Esophageal Neoplasms
Gene Deletion
Genetic Markers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Lymphatic Metastasis

Neoplasm Invasiveness

Neoplasm Staging

Polymorphism, Restriction Fragment Length

Source

Identifiers

PMID: 7907942

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7907942-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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