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Article

Loss of heterozygosity on chromosomes 17 and 18 in breast carcinoma: two additional regions identified.

Proceedings of the National Academy of Sciences of the United States of America - 1 Oct 1990

Cropp C S, Lidereau R, Campbell G, Champene M H, Callahan R

Abstract excerpt

The loss of heterozygosity (LOH) at specific regions of the human genome in tumor DNA is recognized as evidence for a tumor-suppressor gene located within the corresponding region of the homologous chromosome. Restriction fragment length polymorphism analysis of a panel of primary human breast tumor DNAs has led to the identification of two additional regions on chromosomes 17q and 18q that frequently are...

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Identifiers

PMID: 1977164
DOI: 10.1073/pnas.87.19.7737
PMCID: PMC54823

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