Article
Loss of heterozygosity on chromosomes 17 and 18 in breast carcinoma: two additional regions identified.
Proceedings of the National Academy of Sciences of the United States of America - 1 Oct 1990
Cropp C S, Lidereau R, Campbell G, Champene M H, Callahan R
Abstract excerpt
The loss of heterozygosity (LOH) at specific regions of the human genome in tumor DNA is recognized as evidence for a tumor-suppressor gene located within the corresponding region of the homologous chromosome. Restriction fragment length polymorphism analysis of a panel of primary human breast tu...
Topics
- Blotting, Southern
- Breast Neoplasms
- Chromosome Deletion
- Chromosome Mapping
- Chromosomes, Human, Pair 17
- Chromosomes, Human, Pair 18
- DNA Probes
- DNA, Neoplasm
- Female
- Genotype
- Heterozygote
- Humans
- Karyotyping
- Lymphocytes
- Nucleic Acid Hybridization
- Oncogenes
- Polymorphism, Restriction Fragment Length
- Restriction Mapping