Random activation of a transgene under the control of a hybrid hCD2 locus control region/Ig enhancer regulatory element.

doi:10.1002/j.1460-2075.1995.tb07033.x

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Article

Random activation of a transgene under the control of a hybrid hCD2 locus control region/Ig enhancer regulatory element.

The EMBO journal - 1 Feb 1995

Elliott J I, Festenstein R, Tolaini M, Kioussis D

Abstract excerpt

Locus control regions such as those of human CD2 and beta-globin differ from classical enhancers in that, whereas the former confer high level, copy-dependent, position-independent expression to linked genes in transgenic mice, the latter do not, expression levels being dependent on the site of integration. We report that the position independence of the CD2 locus control region is modified by coupling it to the...

Topics

Animals
CD2 Antigens
Chromatin
Chromosome Mapping
Enhancer Elements, Genetic
Flow Cytometry
Gene Expression Regulation
Homozygote
Humans
Immunoglobulin Heavy Chains
Lymph Nodes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Proteins

Mice

Mice, Inbred C57BL

Mice, Inbred CBA

Mice, Transgenic

Phenotype

Promoter Regions, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 7859745
DOI: 10.1002/j.1460-2075.1995.tb07033.x
PMCID: PMC398116

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7859745-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Random activation of a transgene under the control of a hybrid hCD2 locus control region/Ig enhancer regulatory element.PMID 7859745Read ↗

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