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Article

Position effect variegation and imprinting of transgenes in lymphocytes

16 Feb 2008

Abstract excerpt

Sequences proximal to transgene integration sites are able to deregulate transgene expression resulting in complex position effect phenotypes. In addition, transgenes integrated as repeated arrays are susceptible to repeat-induced gene silencing. Using a Cre recombinase-based system we have addressed the influence of transgene copy number (CN) on expression of hCD2 transgenes. CN reduction resulted in a decrease,...

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PMID: 18296483
DOI: 10.1093/nar/gkn085

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