Article
The minimal requirements for activity in transgenic mice of hypersensitive site 3 of the beta globin locus control region.
The EMBO journal - 1 Mar 1993
Philipsen S, Pruzina S, Grosveld F
Abstract excerpt
Proper expression of the human beta-like globin genes is completely dependent on the presence of the locus control region or LCR, a region containing four DNase hypersensitive sites (HS1-4) situated 5' to the structural genes. Linkage of the LCR to a transgene results in copy number-dependent tra...
Topics
- Animals
- Base Sequence
- DNA
- DNA-Binding Proteins
- Erythroid-Specific DNA-Binding Factors
- GATA1 Transcription Factor
- Globins
- Humans
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Mutation