DNaseI hypersensitive sites 1, 2 and 3 of the human beta-globin dominant control region direct position-independent expression.

doi:10.1093/nar/18.12.3503

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Article

DNaseI hypersensitive sites 1, 2 and 3 of the human beta-globin dominant control region direct position-independent expression.

Nucleic acids research - 25 Jun 1990

Fraser P, Hurst J, Collis P, Grosveld F

Abstract excerpt

The human beta-globin dominant control region (DCR) which flanks the multigene beta-globin locus directs high level, site of integration independent, copy number dependent expression on a linked human beta-globin gene in transgenic mice and stably transfected mouse erythroleukemia (MEL) cells. We...

Topics

Animals
Deoxyribonuclease I
Female
Gene Expression Regulation
Genetic Linkage
Globins
Humans
Mice
Mice, Transgenic
Mosaicism
Multigene Family
Mutation
Pregnancy
Restriction Mapping

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