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Article

DNaseI hypersensitive sites 1, 2 and 3 of the human beta-globin dominant control region direct position-independent expression.

Nucleic acids research - 25 Jun 1990

Fraser P, Hurst J, Collis P, Grosveld F

Abstract excerpt

The human beta-globin dominant control region (DCR) which flanks the multigene beta-globin locus directs high level, site of integration independent, copy number dependent expression on a linked human beta-globin gene in transgenic mice and stably transfected mouse erythroleukemia (MEL) cells. We have assayed each of the individual DNaseI hypersensitive regions present in the full 15kb DCR for position...

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Identifiers

PMID: 2362805
DOI: 10.1093/nar/18.12.3503
PMCID: PMC331003

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