Article
Dissection of the locus control function located on the chicken lysozyme gene domain in transgenic mice.
Nucleic acids research - 11 Oct 1994
Bonifer C, Yannoutsos N, Krüger G, Grosveld F, Sippel A E
Abstract excerpt
The entire chicken lysozyme gene locus including all known cis-regulatory sequences and the 5' and 3' matrix attachment sites defining the borders of the DNase I sensitive chromatin domain, is expressed at a high level and independent of its chromosomal position in macrophages of transgenic mice. It was concluded that the lysozyme gene locus carries a locus control function. We analysed several cis-regulatory...
Topics
- Animals
- Chickens
- Chromatin
- DNA
- Deoxyribonuclease I
- Enhancer Elements, Genetic
- Gene Deletion
- Gene Expression
- Macrophages
- Mice
- Mice, Transgenic
- Muramidase