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Article

The polyoma virus enhancer cannot substitute for DNase I core hypersensitive sites 2-4 in the human beta-globin LCR.

Nucleic acids research - 1 Aug 1999

Tanimoto K, Liu Q, Bungert J, Engel J D

Abstract excerpt

The polyoma virus enhancer (PyE) is capable of conferring integration position-independent expression to linked genes in stably transfected erythroid cells after joining to DNase I hypersensitive site (HS) 5 of the human beta-globin locus control region (LCR). In attempting to separate the chromatin opening activity of the LCR from its enhancer activity and to investigate contributions of the individual HS core...

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Share to Chromosomes, Artificial, Yeast
Share to Deoxyribonuclease I

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

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Source

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Identifiers

PMID: 10454609
DOI: 10.1093/nar/27.15.3130
PMCID: PMC148539

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The polyoma virus enhancer cannot substitute for DNase I core hypersensitive sites 2-4 in the human beta-globin LCR.PMID 10454609Read ↗

Hypersensitive site 2 specifies a unique function within the human beta-globin locus control region to stimulate globin gene transcription.Semantic proximity Read ↗

Reconstitution of Human β-Globin Locus Control Region Hypersensitive Sites in the Absence of Chromatin AssemblySemantic proximity Read ↗

Synergistic and additive properties of the beta-globin locus control region (LCR) revealed by 5'HS3 deletion mutations: implication for LCR chromatin architecture.Semantic proximity Read ↗

The beta-globin LCR is not necessary for an open chromatin structure or developmentally regulated transcription of the native mouse beta-globin locus.Semantic proximity Read ↗

Deletion of the core region of 5' HS2 of the mouse beta-globin locus control region reveals a distinct effect in comparison with human beta-globin transgenes.Semantic proximity Read ↗

A mutated polyoma virus enhancer which is active in undifferentiated embryonal carcinoma cells is not repressed by adenovirus-2 E1A products.Semantic proximity Read ↗

DNase I hypersensitivity and epsilon-globin transcriptional enhancement are separable in locus control region (LCR) HS1 mutant human beta-globin YAC transgenic mice.Semantic proximity Read ↗

Conserved elements containing NF-E2 and tandem GATA binding sites are required for erythroid-specific chromatin structure reorganization within the human beta-globin locus control region.Semantic proximity Read ↗

A factor discriminating between the wild-type and a mutant polyomavirus enhancer.Semantic proximity Read ↗

Synergistic regulation of human beta-globin gene switching by locus control region elements HS3 and HS4.Semantic proximity Read ↗

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Definition of transcriptional promoters in the human beta globin locus control region.Semantic proximity Read ↗

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