Article
The murine beta-globin locus control region regulates the rate of transcription but not the hyperacetylation of histones at the active genes.
Proceedings of the National Academy of Sciences of the United States of America - 25 Sept 2001
Schübeler D, Groudine M, Bender M A
Abstract excerpt
Locus control regions (LCRs) are defined by their ability to confer high-level tissue-specific expression to linked genes in transgenic assays. Previously, we reported that, at its native site, the murine beta-globin LCR is required for high-level beta-globin gene expression, but is not required to initiate an open chromatin conformation of the locus. To further investigate the mechanism of LCR-mediated...
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