Article
Saccharomyces cerevisiae SSD1-V confers longevity by a Sir2p-independent mechanism.
Genetics - 1 Apr 2004
Kaeberlein Matt, Andalis Alex A, Liszt Gregory B, Fink Gerald R, Guarente Leonard
Abstract excerpt
The SSD1 gene of Saccharomyces cerevisiae is a polymorphic locus that affects diverse cellular processes including cell integrity, cell cycle progression, and growth at high temperature. We show here that the SSD1-V allele is necessary for cells to achieve extremely long life span. Furthermore, addition of SSD1-V to cells can increase longevity independently of SIR2, although SIR2 is necessary for SSD1-V cells to...
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