Article
SIR2 and other genes are abundantly expressed in long-lived natural segregants for replicative aging of the budding yeast Saccharomyces cerevisiae.
FEMS yeast research - 1 Jun 2011
Guo Zhenhua, Adomas Aleksandra B, Jackson Erin D, Qin Hong, Townsend Jeffrey P
Abstract excerpt
We investigated the mechanism underlying the natural variation in longevity within natural populations using the model budding yeast, Saccharomyces cerevisiae. We analyzed whole-genome gene expression in four progeny of a natural S. cerevisiae strain that display differential replicative aging. Genes with different expression levels in short- and long-lived strains were classified disproportionately into...
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