Article
High frequency of allelic deletion on chromosome 17p in advanced colorectal cancer.
Cancer - 1 Jan 1994
Khine K, Smith D R, Goh H S
Abstract excerpt
BACKGROUND: Colorectal cancers often show allelic loss of chromosomes 5q and 17p, regions where the tumor suppressor genes p53 and adenomatous polyposis coli are known to reside. Currently, the inactivation of tumor suppressor genes and the activation of oncogenes are considered major events involved in tumor development. According to a recent genetic model, ras gene mutations and allelic deletion of chromosome...
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