High frequency of allelic deletion on chromosome 17p in advanced colorectal cancer.

doi:10.1002/1097-0142(19940101)73:1<28::aid-cncr2820730107>3.0.co;2-3

Back to search

Article

High frequency of allelic deletion on chromosome 17p in advanced colorectal cancer.

Cancer - 1 Jan 1994

Khine K, Smith D R, Goh H S

Abstract excerpt

BACKGROUND: Colorectal cancers often show allelic loss of chromosomes 5q and 17p, regions where the tumor suppressor genes p53 and adenomatous polyposis coli are known to reside. Currently, the inactivation of tumor suppressor genes and the activation of oncogenes are considered major events invo...

Topics

Adult
Aged
Aged, 80 and over
Alleles
China
Chromosome Deletion
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 5
Colonic Neoplasms
Female
Gene Deletion
Humans
Lymphatic Metastasis
Male
Middle Aged
Neoplasm Metastasis
Neoplasm Staging
Polymorphism, Genetic

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.