Article
Cytogenetic and germ cell effects of phosphine inhalation by rodents: II. Subacute exposures to rats and mice.
Environmental and molecular mutagenesis - 1 Jan 1994
Kligerman A D, Bishop J B, Erexson G L, Price H C, O'Connor R W, Morgan D L, Zeiger E
Abstract excerpt
Phosphine (PH3) is a highly toxic grain fumigant to which there is significant human workplace exposure. To determine the in vivo cytogenetic effects of inhalation of PH3, male F344/N rats and B6C3F1 mice were exposed to target concentrations of 0, 1.25, 2.5, or 5 ppm PH3 for 6 hr/day for 9 days over an 11-day period. Approximately 20 hr after the termination of exposures, blood was removed from the mice and rats...
Topics
- Administration, Inhalation
- Animals
- Bone Marrow
- Bone Marrow Cells
- Chromosome Aberrations
- Cytochalasin B
- Erythrocytes
- Female
- Germ Cells
- Humans
- Insecticides