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Article

In vivo dominant lethal effect of pyrimethamine in male mouse germ cells.

Mutagenesis - 1 Jan 1999

Egeli U, Aydemir N, Akpinar G, Cimen C, Ergül E, Tutar G, Tunca B, Bilaloğlu R

Abstract excerpt

Pyrimethamine is used for treatment of malaria and toxoplasmosis. The embryotoxicity and clastogenicity of pyrimethamine is known and our aim was to investigate its dominant lethal effect in vivo. For this purpose, we used three groups of Swiss-albino male mice and a control group. We injected males with doses of 16, 32 or 64 mg/kg pyrimethamine and housed them with 10 females/male for each mating interval....

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Identifiers

PMID: 10474824
DOI: 10.1093/mutage/14.1.67

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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