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Unlike other chemicals, etoposide (a topoisomerase-II inhibitor) produces peak mutagenicity in primary spermatocytes of the mouse.

Mutation research - 25 May 1998

Russell L B, Hunsicker P R, Johnson D K, Shelby M D

Abstract excerpt

The cancer chemotherapy agent, and topoisomerase-II inhibitor, etoposide (VP-16) produced both recessive mutations at specific loci and dominants at other loci with peak frequencies in primary spermatocytes, a cell type in which the topo-II gene has been shown to be activated. Etoposide thus differs from all other chemicals whose germ-cell-stage specificity has been analyzed. No effects of etoposide exposure of...

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PMID: 9685680
DOI: 10.1016/s0027-5107(98)00036-0

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