Article
Dimethyl methyl phosphonate induction of dominant lethal mutations in male mice.
Mutation research - 1 Jan 2000
Dunnick J K, Solleveld H A, Harris M W, Chapin R, Lamb J C
Abstract excerpt
The reproductive toxicity of dimethyl methyl phosphonate (DMMP) was studied in the male B6C3F1 mouse. Male mice were treated with 0, 250, 500, 1000, and 2000 mg/kg DMMP by gavage 5 days per week for 13 weeks. After 4, 8 and 12 weeks of treatment the male mice were mated to untreated CD-1 female m...
Topics
- Animals
- Body Weight
- Cholinesterases
- Dose-Response Relationship, Drug
- Follicle Stimulating Hormone
- Genes, Lethal
- Luteinizing Hormone
- Male
- Mice
- Mice, Inbred Strains
- Mutagenicity Tests
- Mutagens
- Mutation
- Organ Size
- Organophosphorus Compounds
- Sperm Count