Article
Hprt mutant frequencies in splenic T-cells of male F344 rats exposed by inhalation to propylene.
Environmental and molecular mutagenesis - 1 Jan 2004
Walker Dale M, Seilkop Steven K, Scott Bobby R, Walker Vernon E
Abstract excerpt
Propylene is a major industrial intermediate and atmospheric pollutant to which humans are exposed by inhalation. In this study, 6-week-old male F344 rates were exposed to 0, 200, 2000, or 10,000 ppm propylene by inhalation for 4 weeks (6 h/day, 5 days/week), and mutant frequencies were determined in the Hprt gene of splenic T-lymphocytes. Twenty milligrams of cyclophosphamide monohydrate (CPP)/kg bw, given on...
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