Article
Relationship between the debrisoquine hydroxylase polymorphism and cancer susceptibility.
Carcinogenesis - 1 Jun 1992
Wolf C R, Smith C A, Gough A C, Moss J E, Vallis K A, Howard G, Carey F J, Mills K, McNee W, Carmichael J
Abstract excerpt
There have been a series of reports on the association of a genetic polymorphism at the cytochrome P450 CYP2D6 gene locus with cancer susceptibility. Many of these reports have remained contradictory either because of small numbers of patients studied or because of the limitations and controversy...
Topics
- Amino Acid Sequence
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- DNA Mutational Analysis
- DNA, Neoplasm
- Disease Susceptibility
- Genetic Carrier Screening
- Humans
- Inactivation, Metabolic
- Mixed Function Oxygenases
- Molecular Sequence Data
- Neoplasms
- Phenotype
- Polymerase Chain Reaction
- Polymorphism, Genetic