Article
Complementation of the ionizing radiation sensitivity, DNA end binding, and V(D)J recombination defects of double-strand break repair mutants by the p86 Ku autoantigen.
Proceedings of the National Academy of Sciences of the United States of America - 31 Jan 1995
Boubnov N V, Hall K T, Wills Z, Lee S E, He D M, Benjamin D M, Pulaski C R, Band H, Reeves W, Hendrickson E A
Abstract excerpt
Two ionizing radiation-sensitive (IRs) and DNA double-strand break (DSB) mutants, sxi-3 and sxi-2, were shown to be severely deficient in a DNA end binding activity, similar to a previously described activity of the Ku autoantigen, correlating with the xrs (XRCC5) mutations. Cell fusions with xrs-6, another IRs, DSB repair-deficient cell line, defined these sxi mutants in the XRCC5 group. sxi-3 cells have low...
Topics
- Animals
- Antigens, Nuclear
- CHO Cells
- Cell Fusion
- Cell Line
- Cricetinae
- DNA
- DNA Damage
- DNA Helicases
- DNA Repair
- DNA-Binding Proteins