Article
Homeodomain protein PRRX1 anchors the Ku heterodimers at DNA double-strand breaks to promote nonhomologous end-joining.
Nucleic acids research - 20 Mar 2025
Wang Yan, Shen Fuyuan, Zhao Chen, Li Jiali, Wang Wen, Li Yamu, Gan Jia, Zhang Haojian, Chen Xuefeng, Chen Qiang, Wang Fangyu, Liu Ying, Zhou Yan
Abstract excerpt
The DNA-dependent protein kinase (DNA-PK) complex plays a critical role in nonhomologous end-joining (NHEJ), a template-independent pathway for repairing DNA double-strand breaks (DSBs). The association of Ku70/80 with DSB ends facilitates the assembly of the DNA-PK holoenzyme. However, key mechanisms underlying the attachment and stabilization of DNA-PK at broken DNA ends remain unclear. Here, we identify PRRX1,...
Read the complete abstract on PubMedTopics
- DNA End-Joining Repair
- Ku Autoantigen
- DNA Breaks, Double-Stranded
- Humans
- Homeodomain Proteins