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Article

Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells.

Genes & development - 15 Dec 2001

Pierce A J, Hu P, Han M, Ellis N, Jasin M

Abstract excerpt

Chromosomal double-strand breaks (DSBs) in mammalian cells are repaired by either homology-directed repair (HDR), using a homologous sequence as a repair template, or nonhomologous end-joining (NHEJ), which often involves sequence alterations at the DSB site. To characterize the interrelationship of these two pathways, we analyzed HDR of a DSB in cells deficient for NHEJ components. We find that the HDR frequency...

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Source

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Identifiers

PMID: 11751629
DOI: 10.1101/gad.946401
PMCID: PMC312854

Genes

XRCC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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