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Article

Deficiency of XLF and PAXX prevents DNA double-strand break repair by non-homologous end joining in lymphocytes

10 Nov 2016

Abstract excerpt

Non-homologous end joining (NHEJ) is a major DNA double-strand break (DSB) repair pathway that functions in all phases of the cell cycle. NHEJ repairs genotoxic and physiological DSBs, such as those generated by ionizing radiation and during V(D)J recombination at antigen receptor loci, respectively. DNA end joining by NHEJ relies on the core factors Ku70, Ku80, XRCC4, and DNA Ligase IV. Additional proteins also...

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Identifiers

PMID: 27830975
DOI: 10.1080/15384101.2016.1253640

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Research trail→

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Deficiency of XLF and PAXX prevents DNA double-strand break repair by non-homologous end joining in lymphocytesPMID 27830975Read ↗

PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repairSemantic proximity Read ↗

XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining.Semantic proximity Read ↗

Leaky severe combined immunodeficiency in mice lacking non-homologous end joining factors XLF and MRI.Semantic proximity Read ↗

PAXX and XLF DNA repair factors are functionally redundant in joining DNA breaks in a G1-arrested progenitor B-cell lineSemantic proximity Read ↗

Functional redundancy between repair factor XLF and damage response mediator 53BP1 in V(D)J recombination and DNA repairSemantic proximity Read ↗

PAXX binding to the NHEJ machinery explains functional redundancy with XLFSemantic proximity Read ↗

PAXX and Xlf interplay revealed by impaired CNS development and immunodeficiency of double KO mice.Semantic proximity Read ↗

An XRCC4 mutant mouse, a model for human X4 syndrome, reveals interplays with Xlf, PAXX, and ATM in lymphoid development.Semantic proximity Read ↗

Robust DNA repair in PAXX ‐deficient mammalian cellsSemantic proximity Read ↗

Evolutionary and functional conservation of the DNA non-homologous end-joining protein, XLF/Cernunnos.Semantic proximity Read ↗

Genetic interaction between DNA repair factors PAXX, XLF, XRCC4 and DNA‐PKcs in human cellsSemantic proximity Read ↗

Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination.Semantic proximity Read ↗

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