Article
Double-strand break repair by Ku70 requires heterodimerization with Ku80 and DNA binding functions.
The EMBO journal - 17 Nov 1997
Jin S, Weaver D T
Abstract excerpt
Heterodimers of the 70 and 80 kDa Ku autoantigens (Ku70 and Ku80) activate the DNA-dependent protein kinase (DNA-PK). Mutations in any of the three subunits of this protein kinase (Ku70, Ku80 and DNA-PKcs) lead to sensitivity to ionizing radiation (IR) and to DNA double-strand breaks, and V(D)J r...
Topics
- Amino Acid Sequence
- Antigens, Nuclear
- Cell Line
- Consensus Sequence
- DNA Damage
- DNA Helicases
- DNA Repair
- DNA-Activated Protein Kinase
- DNA-Binding Proteins
- Dimerization
- Dose-Response Relationship, Radiation
- Genetic Complementation Test
- Humans
- Ku Autoantigen
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Protein Binding