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Article

Double-strand break repair by Ku70 requires heterodimerization with Ku80 and DNA binding functions.

The EMBO journal - 17 Nov 1997

Jin S, Weaver D T

Abstract excerpt

Heterodimers of the 70 and 80 kDa Ku autoantigens (Ku70 and Ku80) activate the DNA-dependent protein kinase (DNA-PK). Mutations in any of the three subunits of this protein kinase (Ku70, Ku80 and DNA-PKcs) lead to sensitivity to ionizing radiation (IR) and to DNA double-strand breaks, and V(D)J recombination product formation defects. Here we show that the IR repair, DNA end binding and DNA-PK defects in Ku70-/-...

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Identifiers

PMID: 9362500
DOI: 10.1093/emboj/16.22.6874
PMCID: PMC1170290

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