Proximal 6q, a region showing allele loss in primary breast cancer.

doi:10.1038/bjc.1995.58

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Article

Proximal 6q, a region showing allele loss in primary breast cancer.

British journal of cancer - 1 Feb 1995

Orphanos V, McGown G, Hey Y, Boyle J M, Santibanez-Koref M

Abstract excerpt

To define regions of deletion of chromosome 6q in breast cancer, we scored 18 (CA)n microsatellites for allelic imbalance (AI) in 42 paired blood/tumour samples. Heterozygosity frequencies of the markers in the sample population ranged from 31% to 92% (mean 68%). Two regions of the chromosome arm...

Topics

Alleles
Base Sequence
Breast Neoplasms
Carcinoma, Ductal, Breast
Chromosome Mapping
Chromosomes, Human, Pair 6
DNA Mutational Analysis
DNA, Neoplasm
DNA, Satellite
Gene Deletion
Genes, Tumor Suppressor
Humans
Molecular Sequence Data

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