Article
Interaction between p53 and TGF beta 1 in control of epithelial cell proliferation.
Oncogene - 19 Jan 1995
Blaydes J P, Schlumberger M, Wynford-Thomas D, Wyllie F S
Abstract excerpt
Although loss of sensitivity to transforming growth factor beta (TGF beta) may be a key step in the escape of epithelial tumours from normal growth control, the intracellular signals determining responsiveness remain controversial, particularly the role of p53. We have investigated this question using thyroid epithelial lines as a model. We analysed (i) human thyroid cancer cell lines having either wild-type (wt)...
Topics
- Animals
- Base Sequence
- Cell Division
- Cell Transformation, Neoplastic
- Genes, ras
- Humans
- Models, Biological
- Molecular Sequence Data
- Mutation
- Rats
- Temperature
- Thyroid Neoplasms