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Article

Evidence for a telomere-independent "clock" limiting RAS oncogene-driven proliferation of human thyroid epithelial cells.

Molecular and cellular biology - 1 Aug 2000

Jones C J, Kipling D, Morris M, Hepburn P, Skinner J, Bounacer A, Wyllie F S, Ivan M, Bartek J, Wynford-Thomas D, Bond J A

Abstract excerpt

An initiating role for RAS oncogene mutation in several epithelial cancers is supported by its high incidence in early-stage tumors and its ability to induce proliferation in the corresponding normal cells in vitro. Using retroviral transduction of thyroid epithelial cells as a model we ask here: (i) how mutant RAS can induce long-term proliferation in an epithelial cell in contrast to the premature senescence...

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Identifiers

PMID: 10891505
DOI: 10.1128/MCB.20.15.5690-5699.2000
PMCID: PMC86042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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