WT1 mutations contribute to abnormal genital system development and hereditary Wilms' tumour.

doi:10.1038/353431a0

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Article

WT1 mutations contribute to abnormal genital system development and hereditary Wilms' tumour.

Nature - 3 Oct 1991

Pelletier J, Bruening W, Li F P, Haber D A, Glaser T, Housman D E

Abstract excerpt

Wilms' tumour (WT), aniridia, genitourinary abnormalities and mental retardation form a symptom group (WAGR syndrome) associated with hemizygous deletions of DNA in chromosome band 11p13 (refs 1,2). However, it has not been clear whether hemizygosity at a single locus contributes to more than one...

Topics

Amino Acid Sequence
Base Sequence
Chromosome Deletion
Exons
Genes, Wilms Tumor
Genitalia, Male
Humans
Kidney Neoplasms
Male
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Wilms Tumor

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