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Article

WT1: a novel tumor suppressor gene inactivated in Wilms' tumor.

The New biologist - 1 Feb 1992

Haber D A, Buckler A J

Abstract excerpt

The development of Wilms' tumor, a pediatric kidney cancer, has been linked to the inactivation of a tumor suppressor gene both by epidemiologic studies and by genetic analyses. Like retinoblastoma, Wilms' tumors can occur bilaterally in individuals with apparent genetic susceptibility to this disease. This led Knudson and Strong to propose in 1972 that two genetic events were rate limiting in tumor development...

Topics

Chromosome Mapping
Chromosomes, Human, Pair 11
Genes, Wilms Tumor
Humans
Kidney Neoplasms
Mutation
Wilms Tumor

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1313285

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1313285-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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