Article
The Wilms tumour gene WT1 in leukaemia.
Leukemia & lymphoma - 1 Oct 1997
Pritchard-Jones K, King-Underwood L
Abstract excerpt
The WT1 gene is essential for kidney development and is mutated in some Wilms tumours. It is also expressed at a high level in many acute leukaemias and in some haematopoietic progenitor cells, and mutations have been found in leukaemias. The function of WT1, which is a zinc finger protein and has domains characteristic of transcription factors, is not well understood. The level of expression is highest in...
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