Article
spitz, a Drosophila homolog of transforming growth factor-alpha, is required in the founding photoreceptor cells of the compound eye facets.
Mechanisms of development - 1 Oct 1994
Tio M, Ma C, Moses K
Abstract excerpt
Cell type specification and differentiation in the developing Drosophila compound eye begins in the morphogenetic furrow. In the furrow, cells are organized into evenly spaced preclusters and there is a synchronized arrest of the cells' mitotic cycle in G1. We report that recessive spitz loss-of-function mutations affect compound eye development. Spitz is homologous to the human transforming growth factor-alpha....
Topics
- Alleles
- Animals
- DNA, Complementary
- Drosophila
- Eye
- Gene Deletion
- In Situ Hybridization
- Microscopy, Electron, Scanning
- Photoreceptor Cells, Invertebrate
- Transforming Growth Factor alpha